Knockdown of V-ATPase subunit A (atp6v1a) impairs acid secretion and ion 5 balance in zebrafish Danio rerio
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چکیده
Jiun-Lin Horng, Li-Yih Lin, Chang-Jen Huang, Fumi Katoh, Toyoji Kaneko and Pung-Pung Hwang 10 1 Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan, ROC 2 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC 3 Department of Life Science, National Taiwan Normal University, Taipei, Taiwan 15 ROC 4 Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan, ROC 5 Department of Biology, St. Francis Xavier University, Antigonish, NS, Canada Page 1 of 45 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (February 1, 2007). doi:10.1152/ajpregu.00578.2006
منابع مشابه
Knockdown of V-ATPase subunit A (atp6v1a) impairs acid secretion and ion balance in zebrafish (Danio rerio).
In the skin of zebrafish embryo, the vacuolar H(+)-ATPase (V-ATPase, H(+) pump) distributed mainly in the apical membrane of H(+)-pump-rich cells, which pump internal acid out of the embryo and function similarly to acid-secreting intercalated cells in mammalian kidney. In addition to acid excretion, the electrogenic H(+) efflux via the H(+)-ATPases in the gill apical membrane of freshwater fis...
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The mechanism of ammonia excretion in freshwater teleosts is not well understood. In this study, scanning ion-selective electrode technique was applied to measure H(+) and NH(4)(+) fluxes in specific cells on the skin of zebrafish larvae. NH(4)(+) extrusion was relatively high in H(+) pump-rich cells, which were identified as the H(+)-secreting ionocyte in zebrafish. Minor NH(4)(+) extrusion wa...
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iv CHAPTER 1. General Introduction 1 CHAPTER 2. Literature Review 5 CHAPTER 3. Rac2 expression in the zebrafish (Danio rerio) 25 CHAPTER 4. Rac2 function in the adult zebrafish neutrophil 45 CHAPTER 5. The effect of Rac2 inhibition and gene knockdown during infectious disease on the mortality of zebrafish (Danio rerio) embryos infected via immersion 61 CHAPTER 6. General Conclusions 75
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Acid-sensing ion channels (ASICs) are epithelial Na(+) channels gated by external H(+). Recently, it has been demonstrated that ASICs play a role in Na(+) uptake in freshwater rainbow trout. Here, we investigate the potential involvement of ASICs in Na(+) transport in another freshwater fish species, the zebrafish (Danio rerio). Using molecular and histological techniques we found that asic gen...
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تاریخ انتشار 2007